产品介绍:
达克替尼（Dacomtinib）是辉瑞公司研发的抗癌新药。获批单药用于表皮生长因子受体（EGFR）19号外显子缺失突变或21号外显子L858R置换突变的局部晚期或转移性非小细胞肺癌患者的一线治疗。
达克替尼属于二代EGFR肺癌靶向药，疗效远胜易瑞沙等一代靶向药。易瑞沙的中位无进展生存期是9.2个月，也就是治疗到9.2个月时，有一半的患者肺癌耐药，病情开始出现进展了。而达可替尼的中位无进展生存期是14.7个月，比易瑞沙延长了5个月以上。而达克替尼对中国患者的中位无进展生存期更是达到18.4个月。
2018年的美国临床肿瘤学会（ASCO）年会上发布数据，携带EGFR敏感基因突变的晚期肺癌患者，如果一线使用达可替尼治疗，平均总生存期是34.1个月，已经接近3年。
【性状】 本品为蓝色薄膜衣片，除去包衣后显白色或类白色。 【适应症】 单药用于表皮生长因子受体（EGFR）19 号外显子缺失突变或 21 号外显子 L858R 置换突变的局部晚期 或转移性非小细胞肺癌（NSCLC）患者的一线治疗。 【规格】 (1) 15 mg; (2) 45 mg 【用法用量】 患者选择 本品应在有使用经验的医疗机构中并在特定的专业技术人员指导下使用。必须基于肿瘤样本经充分验 证的检测方法证实为EGFR 19号外显子缺失突变或21号外显子L858R 置换突变阳性的患者方可使用。
推荐剂量
本品的推荐剂量为每日一次口服 45 mg，直至出现疾病进展或不可接受的毒性。本品可与食物同服， 也可不与食物同服（见【药代动力学】）。 每天在大致相同的时间服用本品。如果患者呕吐或漏服一剂，不应追加剂量或补充服用漏服剂量，而 应在下一次的服药时间服用规定剂量。
生命之源（老挝）医药公司承销
Source of Life Pharmaceutical(Lao)Co.,Ltd
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